Keep at it, eventually there will be a turn around
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ARCA Biopharma, Inc. is a Colorado-based biopharmaceutical company developing genetically-targeted therapies for heart failure and other cardiovascular diseases. Larry interviewed Michael R. Bristow, MD, Ph.D. CEO & Chief Science and Medical Officer of ARCA at the CU Technology Transfer Office Awards banquet. Dr. Bristow has been a favorite interview for w3w3® for years. Larry asked him, "Michael what are the biggest changes you've seen in this last year in your industry?" He replied, "It's been a couple of tough years, but I think things are starting to turn around and basically the atmospherics have gotten a lot better. Just coming off a JP Morgan meeting, it was, I thought, a completely different tone this year." Dr. Bristow had some interesting insights about funding. "Well, it's sort of like financing of real estate was back in the early 80s when interest rates were 20% - you've got to do creative financing. So, all kinds of vehicles have been used through this period. ARCA biopharma, for instance did a reverse merger, bought a company that was NASDAQ listed, that had a bunch of cash - that proved to be a good move. So people have gotten through this one way or another. But we need to get back to traditional sources of funding." Larry asked, "Is there any particular advice to people in your arena?" Spoken like a true leader he replied, "Yes, don't give up. I mean, tenacity, keep at it, eventually there will be a turn around. Now, when things aren't going too well, may be the best opportunity there is in terms of acquiring assets. Think ahead. Think positive." Dr. Bristow joined ARCA as one of ARCA’s founders in September 2004, and has served as Chairman and Chief Science and Medical Officer of ARCA until he was appointed to his current position of Chief Executive Officer in July 2009. Dr. Bristow is a Professor of Medicine and the former Head of Cardiology at the University of Colorado Health Sciences Center, where he has been since October 1991. Dr. Bristow was one of the founders of Myogen, Inc.
Related Links:
ARCA biopharma ||
CU Technology Transfer Office ||
CU TTO Channel ||
TTO Blog ||
CU TTO Awards ||
Award Photos ||
Keywords: Michael Bristow, ARCA biopharma, CU Technology Transfer Office, Biotech,
Cardiology at the University of Colorado Health Sciences Center, University of Colorado Cardiovascular Institute 01/31/11 bytes=2927702
LISTEN to
Michael R. Bristow, MD, Ph.D. CEO & Chief Science and Medical Officer of ARCA
2010 was a pretty vibrant year for entrepreneurship
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Larry asks Brad Feld, founder and managing partner The Foundry Group to take out his crystal ball, but first a snapshot of 2010. Brad said, "2010 was a pretty vibrant year for entrepreneurship, certainly for software and tech entrepreneurship, around the country, but also especially for Boulder, Colorado. Programs like TechStars have helped on a national basis, they have lots of programs throughout the country now. This has really helped with early stage and first-time entrepreneurs. There's plenty of venture capital activity and plenty investments in young growing companies and there have been some very large investments in new leaders, companies like Twitter and Facebook, GroupOn, Zinga. Those companies have both raised a lot of money and they're very substantial business that are generating a lot of cash. We've had a great time together. David has been awesome to work with. He's living in New York right now, for the first quarter running the TechStars New York program, which is now the fourth city that TechStars is in, also Boulder, Boston, and Seattle. NYC is into week three now, off to a great start and he's having a blast. The premise behind TechStars initially, and the thing that David presented to me, that appealed to me so much was this notion of working with first-time entrepreneurs with a mentor driven approach. These types of companies have come to be knows as accelerators. It's a good word, a good description." Larry asked, "How is raising money, either angel or a larger VC investment, different in 2011 from 2010?" Brad replied, "Well, independent of when, raising money for a startup is hard. It's hard when you're at the very beginning and it's hard for 2nd or 3rd round it's even hard when you're raising expansion capital. The mistake that entrepreneurs make is they assume it's going to be straightforward - they expect it to be less difficult than it is. Then when it turns out to be a real slog, it's very difficult for them. So, I don't know that I have any good sense as to whether it'll be any easier or harder to raise money in 2011 because I think it's always hard." If someone is approaching the Foundry Group what shouldn't they do? Brad has advice for entrepreneurs who are seeking money...Listen now...
Related Links:
Foundry Group ||
Feld Thoughts ||
Do More Faster ||
VC Interviews ||
More VC Interviews ||
Keywords: Brad Feld, Foundry Group, Mobius Venture Capital, TechStars, David Cohen,
Defrag, Glue, Blur, Eric Norlin, Do More Faster 01/31/11 bytes=8910788
LISTEN to Brad Feld, Managing Partner, Foundry Group
Who are the winners going to be in the mobile device space
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Jeffrey Pearl and John Scarborough, this time for the Colorado 50 Companies to Watch 2010 Winner Series. We've got background on IP5280 and want to remind you to check out their last interview <<Transformation in the telecommunication industry - 5/24/10>> because we're going to cover new ground here. We start out with a question on the minds of many, What does the merger between Century Link and Qwest mean? John Scarborough said, "It's a pretty significant merger. For Colorado, it is regrettably, another corporate icon, and that's not going to be good for our economy. There's certainly going to be job implications and direct implications to our local economy. That's the biggest impact to us." It is difficult to watch this transpire, but on a high note, John points out, it will translate into new opportunity for entrepreneurial companies like IP5280. Larry asked, "What are some of the keys to success in Colorado's Companies to Watch?" Jeffrey replied, "John and I and the executive team talk a lot about culture - keeping a positive atmosphere, it's fast paced, people can learn new technology, advance in their jobs day-in and day-out, that's really important. Also the hiring process, we're pretty careful about who we bring in, they've got to fit into that culture. On top of that we've just got a lot of cool technology, a really hot market, everything is moving to IP with video on the rise and all those cool things, it's a great place to work." John added, "Voice over IP is gaining credibility, it's gaining legitimacy and it is being adopted very quickly. The big trend at the moment is mobile voice. You know, just as voice over IP is a direct threat to the traditional telephone companies, to the traditional landline services that we all grew up with, so too is mobile voice a threat to the cellular companies that make all these mobile phones operate with that. Now with the proliferation of Wi-Fi communications virtually everywhere you go from Starbucks to your own house, as you enable these mobile devices, cell phones, iPads, iTouches, any kind of device that is able to gain a Wi-Fi or IP connection, that can now be turned into a communications device - a phone in essence. It will begin to directly challenge the traditional mobile community." Then they showed Larry a video phone discussion with one of their clients. "People are familiar with tele conferencing, we now have desktop versions, basically on the phone. We call it the Jetson phone, like the cartoon. We believe that most, if not all of our phones, in the next six to nine months, will be video enabled." Listen as they discuss the iPad and more... Related Links: IP 5280 || Colorado Companies to Watch Home || CCTW Channel || CCTW Event || CCTW Gala Celebration || Keywords: Jeffrey Pearl, John Scarborough, IP 5280, VOIP, Colorado 50 Companies
to Watch, Cellular Networks, Phones, High Definition, Video, IP Services 01/24/11 bytes=7709991
Listen To: Jeffrey Pearl, John Scarborough, IP5280 - Winner of 2010 Colorado Companies to Watch
Funding was a big part of the program 954_ 1/24/11 - Funding was a big topic at the CU Technology Transfer Office Awards banquet. Larry interviewed Dick Hinson who is the senior vice president of the Aurora Economic Development Council. Larry asked, "What's your view on funding today?" Dick replied, "Tonight they've been talking about venture funds and creating a fund of funds in Colorado, to help fund new startups, things like that, moving along the path of 'proof of concept'. I think this is critical because that is the stumbling block for a lot of business development over the past couple of years. You know, the liquidity freeze, the banks haven't been making loans, so it is very very critical that these funds are made available so businesses can expand, do research in areas and the commercialization of what they're trying to do. Larry asked, "Aurora is a very active participant in the business community. Is there anything you're doing in this area as it relates to funding?" Dick replied, "Right now we see a lot of development across the Fitzsimmons/Anschutz Campus that's starting to occur because a developer (Corporex) came along bringing their own funding. They were able to do their own projects and then they had some local help. But that's the critical thing. If we can get the funding, there are a lot of projects ready to go. We've seen this in the Colfax corridor, projects that are ready to go but have been stopped in their tracks for the lack of funding. Over the past couple of years we've seen that same sort of venture capital sort of dry up in Colorado. Hopefully, and from what we've heard here tonight, maybe this is loosening up a little. Once that happens a lot of businesses are going to be able to take advantage of it." Listen now... Related Links: Aurora Economic Development Council || Colorado Business Loan Funds || CU Technology Transfer Office || CU TTO Channel || TTO Blog || CU TTO Awards || Award Photos || Keywords:Dick Hinson, Aurora Economic Development Council, Funding, Venture Capital,
CU Boulder, Technology Transfer Office, Fitzsimmons/Anschutz Campus, Fund of Funds 01/24/11 bytes=2607128
Listen To: Dick Hinson, Sr. VP Aurora Economic Dev Council
Last year was a big year for some
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We're hearing so much about Colorado's venture capital business and the lack of new funds. We contacted Vipanj Patel, managing partner of iSherpa Capital for his take on the situation. A few years back when we talked with Vipanj they were just moving into their offices in Greenwood Village, today they were preparing to move out. That's actually up and out. They're expanding, moving up and taking additional space. Vipanj said, "We're actually going to be housing a couple of companies that we're going to be working with. Actively work in an operating fashion in some of the companies we are investing in and help get them off the ground." Last year was a big year for iSherpa. They expanded beyond wireless into media and entertainment, Internet type of play, a few years ago. There's one company out in San Diego called Taaz, (they do virtual makeovers) that iSherpa invested in about three years ago. Recently hired a new CEO (replacing Vipanj) Harry Lin. "Harry used to run Evite and before that abc.com. He actually was the first one to introduce video to the Internet, well before YouTube and all that. So he's on board full time and running the show day-to-day. He's doing a great job and Taaz is getting a lot of traction. "In the last year we've closed Clinique as a client; rolled out Estée Lauder across 13 countries; In Style magazine, People magazine, Revlon, and we've got quite a few exciting things coming out this year. So that's a company we're excited about." They've grown over 100% each of the last three years. Probably the biggest thing for iSherpa in 2010 was the sale of a company, Sequent, which was in the wireless caller and ID name space, based out of Seattle, WA. iSherpa sold Sequent to a publicly traded company and got a nice exit. Larry asked Vipanj what he saw for VC firms. "It's still an interesting time for the VC industry. The term you'll hear is, 'it's frothy out there right now. There's definitely frothiness in the market, but there are differences too. In other words, back in '99 everyone was chasing everything. The second thing I've seen is a fundamental shift in people's attitude and what it takes to build a business. In the last three years we've been approached by entrepreneurs that have a much more realistic view, in our opinion, of what it takes to build a business. That mind-shift to me has been huge." Vipanj has more to say about wireless...listen now...
Related Links:
iSherpa Capital ||
Taaz ||
Venture Capital ||
Podcasting Directory ||
Keywords: Vipanj Patel, iSherpa Capital, Wireless, Venture Capital, Taaz, Virtual
Makeovers, Sequent, Evite > 01/31/11 bytes=11217923
LISTEN to
Vipanj Patel, Managing Partner, iSherpa Capital
Silicon Valley's biggest IPO since Google
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w3w3® Media Network is proud and honored t
o bring another NCWIT interview to our audience. We've long since recognized the need for education and support for our youth and particularly for young women, in math and science, engineering and technology. The women we interview are bright guiding lights for the future of our youth, generously sharing their experiences - challenges and all. They are inspiring, often humorous and motivating. This series is a real jewel and a valuable set of tools for the future of young women and everyone who has the good fortune to listen. Lucy Sanders, the CEO for the National Center for Women and Information Technology or NCWIT along with Lee Kennedy, Founder, Bolder Search and board member for the National Center for Women and Information Technology or NCWIT along with Larry Nelson, Director of w3w3® Media Network interviewed Diane Greene, founder of VMware. VMware introduced something really innovative which was a virtualization layer between hardware and software that allowed different operating systems to run on the same machine. When the company went public in 2007, it was Silicon Valley's biggest IPO since Google. We asked how she came to be an entrepreneur. Diane explained, "I had always been an organizer, like working with people if their visions are aligned and that led to reading people and being in charge. So, it's a desire to do new things, make things happen. When you need to work on a passion and vision you are sometimes left with no option but to do it yourself. When asked for her advice to young people who are thinking of entrepreneurship, she said. If you see something that really excites you then set about doing it and doing it right. Don't cut any corners, go about it with absolute quality in every way that you approach it and think it through, and execute on it." There's more advice for entrepreneurs.....
Related Links:
NCWIT Home ||
NCWIT Practice ||
VMware ||
Heroes Channel ||
Keywords: Diane Greene, VMware, National Center for Women and Information Technology,
Lucinda Sanders, NCWIT, Lee Kennedy, Bolder Search, Entrepreneurs, Technology 01/31/11 bytes=12086442
LISTEN to Diane Greene, founder VMware
We have actually had a big year
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Dr. Timothy Rodell, the President and CEO of GlobeImmune at the CU Technology Transfer Awards banquet. Larry asked, "It's been over a year since we last interviewed, what's happened during that time?" Dr. Rodell replied, "We've actually had a big year. We completed a large, mid-stage trial in Hepatitis-C patients. To remind you, what we're doing is to use genetically engineered yeast to stimulate the immune system so that it recognizes foreign invaders, and those can be either infectious agents or cancer, it recognizes them and fights against them. What we've now shown in Hepatitis-C is by using our products (called tarmogens) to augment the response, we can actually increase by 25% on a relative basis, the percentage of patients that are cured. So this was a big year for us because I actually could stand up in front of the company, for the very first time and say, "what you've been doing for the last seven years is going to result in people being alive 20 years from now who ultimately would have died of their disease. So that's a really exciting thing. What we're doing now is getting ready for the final stage of trials, called pivotal trials, that could lead to approval and open up commercialization. We hope to start those trials, perhaps by end of 2011. They will run for about two years after that. This is a very challenging time for financing small companies and 2010 was an improvement over 2009 and a major improvement over 2008. But we still have a long way in front of us. So what 2011 is about for us is getting ready to run those pivotal trials in Hepatitis-C and figuring out how we're going to finance those trials..." There's much more, listen now... Related Links: GlobeImmune || CU Technology Transfer Office || CU TTO Channel || TTO Blog || CU TTO Awards || Award Event Photos || Keywords: Dr. Timothy Rodell, CU Boulder, Technology Transfer Office, Hepatitis-C,
Pancreas Cancer, Human Clinical Trials > 01/24/11 bytes=3650354 LISTEN to Dr. Timothy Rodell, GlobeImmune at the Tech Transfer Awards
Helping companies expand their business 955_ 1/24/11 - We've interviewed Vic Ahmed many times over the years and it is particularly exciting today. TiE Rockies, with Vic as president and chairman, has put together a plan for the future of TiE in Colorado. Things have dramatically changed since 2008, and Vic said, "We have to re look at the things we've done in the past and what things we could change and improve to better serve the local entrepreneurial ecosystem." Balan Nair, CTO at Liberty Global, Sureel Choksi, previously with Level3, John Kelley (past CEO, McData), Joe Zell, Grotech Ventures, along with Vic makeup the board of directors. Vic is very excited to have this dynamic and influential group who will take TiE to its next logical destination. "In this context working with the board, and an outstanding group of charter members, we've come up with a very narrowly focused plan. TiE has always done networking, mentoring and educational sessions and will continue to do those. But now we're going to have a focus around three areas. The first and foremost is, funding. We know that Colorado has been challenged with sources of funding, especially in the VC arena - We don't have that many active funds in Colorado anymore. So all the more important to find a bridge to Silicon Valley. In that context we have formed a significant relationship with Plug and Play of Silicon Valley. We're introducing a TiE 50 program where we highlight companies; and then TiE itself has a new group, TiE Angels who make early stage investments. So we are basically launching these programs for the Colorado ecosystem, to assist companies get funding, something which is in dire straits right now. So, that's the first part. The second area TiE is focusing on is helping companies expand their business. "For that", Vic said, "you only have to look at our history. Larry you have been a great supporter of TiE. But TiE has a special connection with India, because of its roots from Indian entrepreneurs in Silicon Valley. We are a powerhouse in India, and India is now the fourth largest economy. No longer is it a destination for only getting IT work done." Vic talks a great deal more about expanding. "The last focus area they've added is Cleantech. "That clearly, remains an area in which Colorado is seen as a global leader. I think it is an opportunity for us to highlight that to a national audience, not just a local audience." Related Links: TiE Rockies || PlugandPlayTechCenter.com || Podcasting Directory || In the News || Keywords: Vic Ahmed, TiE Rockies, Plug and Play Tech Center, Funding, Balan Nair, CTO at Liberty Global, Sureel Choksi, previously with Level3, John Kelley (past CEO, McData), Joe Zell, Grotech Ventures, Colorado Ecosystem
01/24/11 bytes=7087232
Listen To: Vic Ahmed, President & Chairman, TiE Rockies
Achieving Your Personal and Professional Goals 933_ 11/29/10- Don't Let Another Year Go By - The Ultimate Win is Yours - Larry Nelson has taught this material in seminars in over a dozen countries, from China to Canada, from Norway to Australia, from Germany to Japan as well as throughout the USA. He shares the results of his international research about the Characteristics of an Achiever and then goes on to help you lay out your "personalized blueprint" to personal and professional success. Larry is an internationally published author, has been a consultant to many Fortune 1000 companies and is best known for his train-the-trainer programs. ...listen now a complete step-by-step program including a downloadable manual and resource guide...this is an in-depth strategic planning and goal setting system for achievers...Read More about how to Supercharge Your Business... The links below are valuable and extremely helpful to setting your course for the next year! And they're free. Related Links: Ultimate Win Resources || Training Trends || 3-Filters Technology™ || Podcasting Directory || Your Goal || Keywords: Ultimate Win, Your Goal, Training Trends, 3-Filters TechnologyTM, Setting
Goals, Larry Nelson; 11/29/10 Chnl: Entrepreneurs
Change Is Not an Event,
It Is an Ongoing Process
as it is with Chaos
Google ranks Colorado’s w3w3.com in the top 10 for the “Business Internet Talk Radio” show
Google has millions of listings in our category. We are ranked in the top 10. Check it at… The same is true for the category “Entrepreneurs Internet Talk Radio” show…see at…
Coming EVENTS w3w3® Media Network Covers the Best
o bring another NCWIT interview to our audience. We've long since recognized the need for education and support for our youth and particularly for young women, in math and science, engineering and technology. The women we interview are bright guiding lights for the future of our youth, generously sharing their experiences - challenges and all. They are inspiring, often humorous and motivating. This series is a real jewel and a valuable set of tools for the future of young women and everyone who has the good fortune to listen. 
933_ 11/29/10- Don't Let Another Year Go By - The Ultimate Win is Yours - Larry Nelson has taught this material in seminars in over a dozen countries, from China to Canada, from Norway to Australia, from Germany to Japan as well as throughout the USA. He shares the results of his international research about the Characteristics of an Achiever and then goes on to help you lay out your "personalized blueprint" to personal and professional success. Larry is an internationally published author, has been a consultant to many Fortune 1000 companies and is best known for his train-the-trainer programs. ...listen now a complete step-by-step program including a downloadable manual and resource guide...this is an in-depth strategic planning and goal setting system for achievers..
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